Note 18 - Supplemental Financial Information (Tables)

12 Months Ended

Dec. 31, 2020

	Three months ended
	March 31, 2020			June 30, 2020			September 30, 2020			December 31, 2020			Total for year 2020

Product sales	$	18		$	—		$	90			—		$	108

Operating cost and expense
Cost of product sales		1,454			1,306			1,635			1,081			5,476
Research and development cost		242			217			210			358			1,027
General and administrative expense		2,385			2,245			1,656			2,712			8,998
Total operating expenses		4,081			3,768			3,501			4,151			15,501
Loss from operations		(4,063	)		(3,768	)		(3,411	)		(4,151	)		(15,393	)
Other income and expense
Insurance proceeds net of related expenses		(203	)		(52	)		1,722			1,479			2,946
Impairment expense		—			—			—			(11,741	)		(11,741	)
Interest expense		(183	)		(164	)		(166	)		(1,107	)		(1,620	)
Interest and other income		22			3			18			5			48
Total other expense, net		(364	)		(213	)		1,574			(11,364	)		(10,367	)

Loss before income tax expense		(4,427	)		(3,981	)		(1,837	)		(15,515	)		(25,760	)
Income tax expense		—			(2	)		—			—			(2	)
Net loss	$	(4,427	)	$	(3,983	)	$	(1,837	)	$	(15,515	)	$	(25,762	)
Weighted average shares outstanding, basic and diluted		59,582,603			60,136,374			60,998,971			62,136,421			60,861,450
Basic and diluted net loss per share	$	(0.07	)	$	(0.07	)	$	(0.03	)	$	(0.25	)	$	(0.42	)

	Three months ended
	March 31, 2019			June 30, 2019			September 30, 2019			December 31, 2019			Total for year 2019

Product sales	$	437		$	1,483		$	2,361		$	593		$	4,874

Operating cost and expense
Cost of product sales		4,681			7,185			8,231			4,702			24,799
Research and development cost		620			338			282			315			1,555
General and administrative expense		4,016			4,335			5,107			5,856			19,314
Total operating expenses		9,317			11,858			13,620			10,873			45,668
Loss from operations		(8,880	)		(10,375	)		(11,259	)		(10,280	)		(40,794	)
Other income and expense
Insurance proceeds net of related expenses		—			—			—			(792	)		(792	)
Interest expense		(2,889	)		(203	)		(142	)		(243	)		(3,477	)
Interest and other income		63			77			85			45			270
Total other expense, net		(2,826	)		(126	)		(57	)		(990	)		(3,999	)
Loss before income tax expense		(11,706	)		(10,501	)		(11,316	)		(11,270	)		(44,793	)
Income tax expense		(2	)		—			—			—			(2	)
Net loss	$	(11,708	)	$	(10,501	)	$	(11,316	)	$	(11,270	)	$	(44,795	)
Weighted average shares outstanding, basic and diluted		43,514,225			50,757,448			57,053,982			57,523,283			52,263,885
Basic and diluted net loss per share	$	(0.27	)	$	(0.21	)	$	(0.20	)	$	(0.20	)	$	(0.86	)